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Issue 5, 2015
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A label-free and sensitive fluorescent method for the detection of uracil-DNA glycosylase activity

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Abstract

The activity of uracil-DNA glycosylase (UDG), an enzyme in the base excision repair, is detected at a high sensitivity by a DNA substrate containing only one uracil through a label-free fluorescent approach, which is also successfully applied for the measurement of UDG inhibitors.

Graphical abstract: A label-free and sensitive fluorescent method for the detection of uracil-DNA glycosylase activity

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Publication details

The article was received on 07 Aug 2014, accepted on 04 Nov 2014 and first published on 04 Nov 2014


Article type: Communication
DOI: 10.1039/C4CC06170E
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Citation: Chem. Commun., 2015,51, 929-932

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    A label-free and sensitive fluorescent method for the detection of uracil-DNA glycosylase activity

    J. Tao, P. Song, Y. Sato, S. Nishizawa, N. Teramae, A. Tong and Y. Xiang, Chem. Commun., 2015, 51, 929
    DOI: 10.1039/C4CC06170E

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