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Issue 5, 2015
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Oxidative regioselective amination of chromones exposes potent inhibitors of the hedgehog signaling pathway

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Abstract

A transition metal-free, oxidative, regioselective cross-coupling between non-functionalized azoles and chromones at C2-position was developed. A broad reaction scope and further transformation of products were demonstrated. The biological evaluation of products revealed a novel class of hedgehog signaling pathway inhibitors.

Graphical abstract: Oxidative regioselective amination of chromones exposes potent inhibitors of the hedgehog signaling pathway

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Publication details

The article was received on 23 Oct 2014, accepted on 25 Nov 2014 and first published on 25 Nov 2014


Article type: Communication
DOI: 10.1039/C4CC08376H
Citation: Chem. Commun., 2015,51, 925-928
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    Oxidative regioselective amination of chromones exposes potent inhibitors of the hedgehog signaling pathway

    R. Samanta, R. Narayan, J. O. Bauer, C. Strohmann, S. Sievers and A. P. Antonchick, Chem. Commun., 2015, 51, 925
    DOI: 10.1039/C4CC08376H

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