Issue 90, 2015

Stability and its manifestation in the chemical and biological worlds


Bridging between the phenomenologically distinct biological and physical worlds has been a major scientific challenge since Boltzmann's probabilistic formulation of the second law of thermodynamics. In this review we summarize our recent theoretical attempts to bridge that divide through analysis of the thermodynamic-kinetic interplay in chemical processes and the manner in which that interplay impacts on material stability. Key findings are that the term ‘stability’ manifests two facets – time and energy – and that stability's time facet, expressed as persistence, is more general than its energy facet. That idea, together with the proposed existence of a logical law of nature, the persistence principle, leads to the mathematically-based insight that stability can come about through either Boltzmann's probabilistic considerations or Malthusian kinetics. Two mathematically-based forms of material persistence then lead directly to the physical likelihood of two material forms, animate and inanimate. Significantly, the incorporation of kinetic considerations into the stability concept appears to bring us closer to enabling two of the central theories in science – the second law of thermodynamics and Darwin's theory of evolution – to be reconciled within a single conceptual framework.

Graphical abstract: Stability and its manifestation in the chemical and biological worlds

Article information

Article type
Feature Article
26 Jul 2015
07 Oct 2015
First published
07 Oct 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 16160-16165

Author version available

Stability and its manifestation in the chemical and biological worlds

R. Pascal and A. Pross, Chem. Commun., 2015, 51, 16160 DOI: 10.1039/C5CC06260H

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