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Issue 67, 2015
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Higher-order human telomeric G-quadruplex DNA metalloenzyme catalyzed Diels–Alder reaction: an unexpected inversion of enantioselectivity modulated by K+ and NH4+ ions

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Abstract

We report that K+ and NH4+ present different allosteric activation for higher-order human telomeric G-quadruplex DNA metalloenzyme. The obtained major endo products of Diels–Alder reaction can be switched from one preferred configuration in K+ media (up to 92% ee) to its mirror configuration in NH4+ media (up to −90% ee).

Graphical abstract: Higher-order human telomeric G-quadruplex DNA metalloenzyme catalyzed Diels–Alder reaction: an unexpected inversion of enantioselectivity modulated by K+ and NH4+ ions

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Publication details

The article was received on 25 Jun 2015, accepted on 08 Jul 2015 and first published on 08 Jul 2015


Article type: Communication
DOI: 10.1039/C5CC05215G
Citation: Chem. Commun., 2015,51, 13174-13177

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    Higher-order human telomeric G-quadruplex DNA metalloenzyme catalyzed Diels–Alder reaction: an unexpected inversion of enantioselectivity modulated by K+ and NH4+ ions

    Y. Li, C. Wang, J. Hao, M. Cheng, G. Jia and C. Li, Chem. Commun., 2015, 51, 13174
    DOI: 10.1039/C5CC05215G

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