Issue 67, 2015
From the journal:

Chemical Communications

Self-assembly induced solubilization of drug-like molecules in nanostructured ionic liquids†

Wenbin Jin,a   Qiwei Yang,a   Zhiguo Zhang,a   Zongbi Bao,a   Qilong Ren,a   Yiwen Yanga  and  Huabin Xing*a  

* Corresponding authors

a Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China
E-mail: xinghb@zju.edu.cn

Abstract

Here we report a novel self-assembly induced solubilization strategy with nanostructured ionic liquids as solvents. Highly ordered mesoscopic structures featuring the solute as a key component, such as liquid crystals, were formed via self-assembly in nanostructured long-chain carboxylate ionic liquids, resulting in extremely high solubilities for sparingly soluble drug molecules.

Graphical abstract: Self-assembly induced solubilization of drug-like molecules in nanostructured ionic liquids

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Article information

DOI
https://doi.org/10.1039/C5CC03463A
Article type
Communication
Submitted
26 Apr 2015
Accepted
01 Jul 2015
First published
01 Jul 2015

Chem. Commun., 2015,51, 13170-13173

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Self-assembly induced solubilization of drug-like molecules in nanostructured ionic liquids

W. Jin, Q. Yang, Z. Zhang, Z. Bao, Q. Ren, Y. Yang and H. Xing, Chem. Commun., 2015, 51, 13170 DOI: 10.1039/C5CC03463A

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