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Issue 73, 2015
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Transiently responsive protein–polymer conjugates via a ‘grafting-from’ RAFT approach for intracellular co-delivery of proteins and immune-modulators

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Abstract

We report on transiently responsive protein–polymer conjugates that temporarily change their protein conformation from the soluble to the particle-like state. ‘Grafting-from’ RAFT polymerization of a dioxolane-containing acrylamide with a protein macroCTA is used to design polymer–protein conjugates that self-assemble into nanoparticles at physiological temperature and pH. Acid triggered hydrolysis of the dioxolane units into diol moeities rendered the conjugates fully water soluble irrespective of temperature.

Graphical abstract: Transiently responsive protein–polymer conjugates via a ‘grafting-from’ RAFT approach for intracellular co-delivery of proteins and immune-modulators

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Publication details

The article was received on 10 Jun 2015, accepted on 13 Jul 2015 and first published on 13 Jul 2015


Article type: Communication
DOI: 10.1039/C5CC04809E
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Citation: Chem. Commun., 2015,51, 13972-13975
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    Transiently responsive protein–polymer conjugates via a ‘grafting-from’ RAFT approach for intracellular co-delivery of proteins and immune-modulators

    N. Vanparijs, R. De Coen, D. Laplace, B. Louage, S. Maji, L. Lybaert, R. Hoogenboom and B. G. De Geest, Chem. Commun., 2015, 51, 13972
    DOI: 10.1039/C5CC04809E

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