Issue 62, 2015

Fluorophore ATCUN complexes: combining agent and probe for oxidative DNA cleavage

Abstract

DNA can be oxidatively cleaved by copper complexes of the ATCUN peptide (amino terminal Cu(II)- and Ni(II)-binding motif). In order to investigate the fate of the metal ion throughout this process, we have exploited quenching/dequenching effects of conjugated fluorophores.

Graphical abstract: Fluorophore ATCUN complexes: combining agent and probe for oxidative DNA cleavage

Supplementary files

Article information

Article type
Communication
Submitted
03 Jun 2015
Accepted
22 Jun 2015
First published
22 Jun 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 12395-12398

Author version available

Fluorophore ATCUN complexes: combining agent and probe for oxidative DNA cleavage

C. Wende and N. Kulak, Chem. Commun., 2015, 51, 12395 DOI: 10.1039/C5CC04508H

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