Issue 60, 2015

Selective targeting of Mycobacterium smegmatis with trehalose-functionalized nanoparticles

Abstract

Silica and iron oxide nanoparticles with sizes ranging from 6 to 40 nm were functionalized with trehalose. The trehalose-conjugated nanoparticles showed strong interactions with Mycobacterium smegmatis (M. smegmatis) and minimal interactions with macrophage (RAW 264.7) or A549 cells. In addition, trehalose-conjugated silica nanoparticles selectively interacted with M. smegmatis on M. smegmatis-treated A549 cells, demonstrating high potential of trehalose in developing targeted therapy for treating mycobacterial infection.

Graphical abstract: Selective targeting of Mycobacterium smegmatis with trehalose-functionalized nanoparticles

Supplementary files

Article information

Article type
Communication
Submitted
23 May 2015
Accepted
15 Jun 2015
First published
16 Jun 2015

Chem. Commun., 2015,51, 12028-12031

Author version available

Selective targeting of Mycobacterium smegmatis with trehalose-functionalized nanoparticles

K. W. Jayawardana, H. S. N. Jayawardena, S. A. Wijesundera, T. De Zoysa, M. Sundhoro and M. Yan, Chem. Commun., 2015, 51, 12028 DOI: 10.1039/C5CC04251H

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