A switch-on MRI contrast agent for noninvasive visualization of methylmercury

Abstract

This communication presents the first Gd(III)-based T₁ MRI contrast agent, o-MeHgGad, for noninvasive visualization of CH₃Hg⁺. o-MeHgGad showed a relaxivity enhancement of 62% in the presence of 1 equiv. of CH₃Hg⁺. Moreover, a noticeable contrast enhancement was recorded in the liver, kidney, and intestine of mice exposed to CH₃Hg⁺. Thus, the newly designed contrast agent has the potential to be used for in vivo bio-imaging of CH₃Hg⁺ and could be useful for biomedical applications.