Issue 62, 2015

5′- vs. 3′-end sugar conformational control in shaping up dinucleotides

Abstract

The 5′-end N-sugar puckering is currently believed to govern the intramolecular dinucleotide stacking. We demonstrate that if this 5′-conformation is indeed important in shaping up dinucleotide structures, the 3′-end sugar conformation can either potentiate or cancel the stacking capacity induced by the 5′-end N-sugar conformation.

Graphical abstract: 5′- vs. 3′-end sugar conformational control in shaping up dinucleotides

Supplementary files

Article information

Article type
Communication
Submitted
21 May 2015
Accepted
23 Jun 2015
First published
03 Jul 2015

Chem. Commun., 2015,51, 12381-12383

5′- vs. 3′-end sugar conformational control in shaping up dinucleotides

J. Jakhlal, S. Coantic-Castex, C. Denhez, C. Petermann, A. Martinez, D. Harakat, D. Guillaume and P. Clivio, Chem. Commun., 2015, 51, 12381 DOI: 10.1039/C5CC04212G

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