Issue 36, 2015

Multi-layered polymeric nanoparticles for pH-responsive and sequenced release of theranostic agents

Abstract

In this study, multi-layered pH-responsive polymeric nanoparticles (NPs) are prepared by multiple (up to 4) emulsifications to encapsulate multiple hydrophilic and hydrophobic theranostic agents for controlled and sequenced release. It is found that the sequence of release of multiple chemotherapeutic agents from the NPs significantly affects their efficacy against cancer cells.

Graphical abstract: Multi-layered polymeric nanoparticles for pH-responsive and sequenced release of theranostic agents

Supplementary files

Article information

Article type
Communication
Submitted
04 Mar 2015
Accepted
28 Mar 2015
First published
30 Mar 2015

Chem. Commun., 2015,51, 7733-7736

Author version available

Multi-layered polymeric nanoparticles for pH-responsive and sequenced release of theranostic agents

H. Wang, S. Zhao, P. Agarwal, J. Dumbleton, J. Yu, X. Lu and X. He, Chem. Commun., 2015, 51, 7733 DOI: 10.1039/C5CC01833A

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