Issue 50, 2015
From the journal:

Chemical Communications

Highly sensitive turn-on biosensors by regulating fluorescent dye assembly on liposome surfaces†

Sungbaek Seo,‡a   Min Sang Kwon,‡b   Andrew W. Phillips,‡a   Deokwon Seob  and  Jinsang Kim*abcde  

* Corresponding authors

a Macromolecular Sci. and Eng., University of Michigan, USA

b Materials Sci. and Eng., University of Michigan, USA

c Chemical Eng., University of Michigan, USA

d Biomedical Eng., University of Michigan, USA

e Chemistry, University of Michigan, USA
E-mail: jinsang@umich.edu

Abstract

We developed a new self-signaling sensory system built on phospholipid liposomes having H-aggregated R6G dyes on their surface. Selective molecular recognition of a target by the phospholipid displaces R6G from the liposome surface to turn on fluorescence signal. Selective and sensitive detection of neomycin down to 2.3 nM is demonstrated.

Graphical abstract: Highly sensitive turn-on biosensors by regulating fluorescent dye assembly on liposome surfaces

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Article information

DOI
https://doi.org/10.1039/C5CC01621E
Article type
Communication
Submitted
23 Feb 2015
Accepted
14 May 2015
First published
14 May 2015

Chem. Commun., 2015,51, 10229-10232

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Highly sensitive turn-on biosensors by regulating fluorescent dye assembly on liposome surfaces

S. Seo, M. S. Kwon, A. W. Phillips, D. Seo and J. Kim, Chem. Commun., 2015, 51, 10229 DOI: 10.1039/C5CC01621E

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