Issue 14, 2015
From the journal:

Chemical Communications

Cationic fluorescent polymer core–shell nanoparticles for encapsulation, delivery, and non-invasively tracking the intracellular release of siRNA†

Ji-Cheng Yu,‡a   Sha Zhu,‡a   Pei-Jian Feng,a   Cheng-Gen Qian,a   Jun Huang,a   Min-Jie Sunb  and  Qun-Dong Shen*a  

* Corresponding authors

a Department of Polymer Science & Engineering and Key Laboratory of High Performance Polymer Materials & Technology of MOE, School of Chemistry & Chemical Engineering, Nanjing University, Nanjing, China
E-mail: qdshen@nju.edu.cn
Fax: +86-25-8331-7761
Tel: +86-25-8331-7807

b Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China

Abstract

A multifunctional nanocarrier for encapsulation and delivery of short interfering RNA (siRNA) has been realized using cationic fluorescent polymer core–shell nanoparticles. The nanocarrier has good biocompatibility and high transfection efficiency over the most popular transfection reagent, Lipofectamine 2000. Fluorescence resonance energy transfer within the nanocarrier provides a non-invasive and label-free method to track the intracellular release of siRNA.

Graphical abstract: Cationic fluorescent polymer core–shell nanoparticles for encapsulation, delivery, and non-invasively tracking the intracellular release of siRNA

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Article information

DOI
https://doi.org/10.1039/C4CC09685A
Article type
Communication
Submitted
04 Dec 2014
Accepted
13 Jan 2015
First published
13 Jan 2015

Chem. Commun., 2015,51, 2976-2979

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Cationic fluorescent polymer core–shell nanoparticles for encapsulation, delivery, and non-invasively tracking the intracellular release of siRNA

J. Yu, S. Zhu, P. Feng, C. Qian, J. Huang, M. Sun and Q. Shen, Chem. Commun., 2015, 51, 2976 DOI: 10.1039/C4CC09685A

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