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Issue 8, 2015
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Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates

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Abstract

Engineered variants of the heme-containing protein myoglobin can efficiently catalyze the insertion of α-diazo esters into the N–H bond of arylamines, featuring a combination of high chemoselectivity, elevated turnover numbers, and broad substrate scope.

Graphical abstract: Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates

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Supplementary files

Article information


Submitted
03 Nov 2014
Accepted
02 Dec 2014
First published
03 Dec 2014

Chem. Commun., 2015,51, 1532-1534
Article type
Communication
Author version available

Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates

G. Sreenilayam and R. Fasan, Chem. Commun., 2015, 51, 1532
DOI: 10.1039/C4CC08753D

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