Issue 16, 2015

A robust and modular synthesis of ynamides

Abstract

A flexible, modular ynamide synthesis is reported that uses trichloroethene as an inexpensive two carbon synthon. A wide range of amides and electrophiles can be converted to the corresponding ynamides, importantly including acyclic carbamates, hindered amides, and aryl amides. This method thus overcomes many of the limitations of other approaches to this useful functionality.

Graphical abstract: A robust and modular synthesis of ynamides

Supplementary files

Article information

Article type
Communication
Submitted
07 Oct 2014
Accepted
29 Oct 2014
First published
06 Nov 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 3316-3319

Author version available

A robust and modular synthesis of ynamides

S. J. Mansfield, C. D. Campbell, M. W. Jones and E. A. Anderson, Chem. Commun., 2015, 51, 3316 DOI: 10.1039/C4CC07876D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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