Issue 16, 2015

A robust and modular synthesis of ynamides


A flexible, modular ynamide synthesis is reported that uses trichloroethene as an inexpensive two carbon synthon. A wide range of amides and electrophiles can be converted to the corresponding ynamides, importantly including acyclic carbamates, hindered amides, and aryl amides. This method thus overcomes many of the limitations of other approaches to this useful functionality.

Graphical abstract: A robust and modular synthesis of ynamides

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Article information

Article type
07 Oct 2014
29 Oct 2014
First published
06 Nov 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 3316-3319

Author version available

A robust and modular synthesis of ynamides

S. J. Mansfield, C. D. Campbell, M. W. Jones and E. A. Anderson, Chem. Commun., 2015, 51, 3316 DOI: 10.1039/C4CC07876D

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