Issue 2, 2015
From the journal:

Chemical Communications

DNA photocleavage in anaerobic conditions by a Ru(ii) complex: a new mechanism†

Yue Zheng,ab   Qianxiong Zhou,*a   Wanhua Lei,a   Yuanjun Hou,a   Ke Li,ab   Yongjie Chen,ab   Baowen Zhanga  and  Xuesong Wang*a  

* Corresponding authors

a Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
E-mail: xswang@mail.ipc.ac.cn, zhouqianxiong@mail.ipc.ac.cn
Fax: +86-10-62564049
Tel: +86-10-82543592

b Graduate School of Chinese Academy of Sciences, Beijing 100049, P. R. China

Abstract

[Ru(bpy)2(py-SO3)]+ (bpy = 2,2′-bipyridine and py-SO3 = pyridine-2-sulfonate) was found to undergo py-SO3 dissociation upon visible light irradiation (≥470 nm) via Ru–O homolysis, producing reactive free radical species, and is thus able to not only photobind but also photocleave DNA in hypoxic conditions.

Graphical abstract: DNA photocleavage in anaerobic conditions by a Ru(ii) complex: a new mechanism

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Article information

DOI
https://doi.org/10.1039/C4CC06552B
Article type
Communication
Submitted
20 Aug 2014
Accepted
04 Nov 2014
First published
06 Nov 2014

Chem. Commun., 2015,51, 428-430

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DNA photocleavage in anaerobic conditions by a Ru(II) complex: a new mechanism

Y. Zheng, Q. Zhou, W. Lei, Y. Hou, K. Li, Y. Chen, B. Zhang and X. Wang, Chem. Commun., 2015, 51, 428 DOI: 10.1039/C4CC06552B

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