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Issue 37, 2014
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Silver- and sulfadiazine-loaded nanostructured silica materials as potential replacement of silver sulfadiazine

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Abstract

Silver sulfadiazine (AgSD) is the leading topical antibacterial agent for the treatment of burn wound infections. Antibacterial effect of AgSD is limited by its poor aqueous solubility, and antibacterial activity develops only by decomposition of AgSD to silver ions and sulfadiazine. In this study, it is for the first time that application of silver-modified nanoporous silica carriers (MCM-41 or SBA-15) loaded with sulfadiazine (SD), instead of silver sulfadiazine, overcoming the abovementioned disadvantages has been demonstrated. By direct or post synthesis methods, 5–15 nm sized silver nanoparticles can be stabilized in the channels or on the outer surface of nanoporous silica supports; moreover, the empty channels can be loaded by SD molecules. The SD-loaded, silver-modified materials show sustained release properties and similar or even better antimicrobial properties than AgSD. Adsorption of AgSD on nanoporous silica particles significantly improves its water solubility.

Graphical abstract: Silver- and sulfadiazine-loaded nanostructured silica materials as potential replacement of silver sulfadiazine

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Publication details

The article was received on 18 Apr 2014, accepted on 09 Jul 2014 and first published on 09 Jul 2014


Article type: Paper
DOI: 10.1039/C4TB00619D
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J. Mater. Chem. B, 2014,2, 6283-6292

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    Silver- and sulfadiazine-loaded nanostructured silica materials as potential replacement of silver sulfadiazine

    Á. Szegedi, M. Popova, K. Yoncheva, J. Makk, J. Mihály and P. Shestakova, J. Mater. Chem. B, 2014, 2, 6283
    DOI: 10.1039/C4TB00619D

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