Expedient synthesis of a pentasaccharide related to the O-specific polysaccharide of Escherichia coli O117:K98:H4 strain

Abstract

A convenient synthetic strategy has been developed for the synthesis of a pentasaccharide, related to the O-specific polysaccharide of Escherichia coli O117:K98:H4 strain, using sequential glycosylations of functionalized monosaccharide moieties. The application of a one-pot reaction condition for two glycosylations and in situ PMB group removal reduced the number of reaction steps significantly. All glycosylation reactions were stereoselective with satisfactory yield.