Facile synthesis of a reduction-responsive amphiphilic triblock polymer via a selective thiol–disulfide exchange reaction†
Abstract
A reduction-responsive amphiphilic triblock copolymer mPEG-b-PDS-b-mPEG was synthesized via polycondensation between a dithiol and dipyridyl disulfide, followed by a selective thiol–disulfide exchange reaction. The reduction-triggered release of Nile Red by DTT was further demonstrated using fluorescence spectroscopy.