A highly regio- and stereoselective [4 + 2] formal cycloaddition process of cyclohexenylidenemalononitriles and α,β-unsaturated aldehydes has been developed by the catalysis of a chiral secondary amine, affording a range of bridged bicyclo[2.2.2]octane architectures with high molecular complexity (up to 98% ee, >19:1 d.r.).
![Graphical abstract: Organocatalytic asymmetric [4 + 2] formal cycloadditions of cyclohexenylidenemalononitriles and enals to construct chiral bicyclo[2.2.2]octanes](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C4RA07709A&imageInfo.ImageIdentifier.Year=2014)
Q. Li, J. Gu and Y. Chen, RSC Adv., 2014, 4, 37522 DOI: 10.1039/C4RA07709A
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