Issue 57, 2014

Fluorescent and antioxidant studies of effectively synthesized isochromenopyrrolone analogues

Abstract

An efficient strategy for the synthesis of 3-acetyl-2-methyl-1-phenylisochromeno [4,3-b] pyrrol-5(1H)-ones 4a–f have been developed using montmorillonite K10 as a catalyst. The reaction proceeded from acetyl acetone, substituted primary amines and ninhydrin via acidic media under solvent-free conditions. Compounds 4a–c exhibit green fluorescence under UV light, and their fluorescent properties in the liquid state were investigated. All the synthesized compounds were subjected for the evaluation of their free radical scavenging activity. Among all the tested compounds 4a and 4c exhibited good percentage inhibition in comparison with the standard, i.e. ascorbic acid.

Graphical abstract: Fluorescent and antioxidant studies of effectively synthesized isochromenopyrrolone analogues

Article information

Article type
Paper
Submitted
29 Mar 2014
Accepted
17 Jun 2014
First published
17 Jun 2014

RSC Adv., 2014,4, 29999-30003

Author version available

Fluorescent and antioxidant studies of effectively synthesized isochromenopyrrolone analogues

H. R. Reddy, C. V. Subba Reddy, R. Subashini and S. M. Roopan, RSC Adv., 2014, 4, 29999 DOI: 10.1039/C4RA02792B

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