Issue 36, 2014
From the journal:

RSC Advances

Three component synthesis of 2-oxindole via sequential Michael addition, intramolecular cyclization and aromatization†

Muthusamy Boominathan,a   Muthupandi Nagaraj,a   Shanmugam Muthusubramanian*a  and  Nattamai Bhuvaneshb  

* Corresponding authors

a School of Chemistry, Madurai Kamaraj University, Madurai – 625 021, India
E-mail: muthumanian2001@yahoo.com
Fax: +91-452-2459139
Tel: +91-452-2458246

b X-ray Diffraction Laboratory, Department of Chemistry, Texas A&M University, College station, Texas 77842, USA

Abstract

An easy metal free access to the synthesis of medicinally promising 2-oxindole derivatives via a tandem enamine formation – Michael addition – regiospecific intramolecular cyclization – aromatization sequence promoted by trifluoroacetic acid has been described. This three component reaction is regiospecific with good yield and satisfactory atom economy.

Graphical abstract: Three component synthesis of 2-oxindole via sequential Michael addition, intramolecular cyclization and aromatization

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Article information

DOI
https://doi.org/10.1039/C4RA02091J
Article type
Paper
Submitted
10 Mar 2014
Accepted
07 Apr 2014
First published
09 Apr 2014

RSC Adv., 2014,4, 18549-18557

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Three component synthesis of 2-oxindole via sequential Michael addition, intramolecular cyclization and aromatization

M. Boominathan, M. Nagaraj, S. Muthusubramanian and N. Bhuvanesh, RSC Adv., 2014, 4, 18549 DOI: 10.1039/C4RA02091J

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