Issue 36, 2014
From the journal:

RSC Advances

Efficient synthesis of 2,4-disubstituted quinolines: calix[n]arene-catalyzed Povarov-hydrogen-transfer reaction cascade†

Juliana Baptista Simões,ab   Ângelo de Fátima,c   Adão Aparecido Sabino,c   Luiz Claudio Almeida Barbosac  and  Sergio Antonio Fernandes*a  

* Corresponding authors

a Departamento de Química, CCE, Universidade Federal de Viçosa, Viçosa, MG, Brazil
E-mail: santonio@ufv.br, sefernandes@gmail.com

b Departamento de Ensino de Ciências, Instituito Federal de Educação Ciência e Tecnologia Fluminense, Itaperuna, RJ, Brazil

c Departamento de Química, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

Abstract

A cascade process involving the Povarov reaction and hydrogen transfer catalyzed with p-sulfonic acid calix[4]arene was disclosed and afforded the synthesis of 2,4-disubstituted quinolines in good yields under appropriate conditions in a single pot process.

Graphical abstract: Efficient synthesis of 2,4-disubstituted quinolines: calix[n]arene-catalyzed Povarov-hydrogen-transfer reaction cascade

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Article information

DOI
https://doi.org/10.1039/C4RA02036G
Article type
Communication
Submitted
08 Mar 2014
Accepted
08 Apr 2014
First published
09 Apr 2014

RSC Adv., 2014,4, 18612-18615

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Efficient synthesis of 2,4-disubstituted quinolines: calix[n]arene-catalyzed Povarov-hydrogen-transfer reaction cascade

J. B. Simões, Â. de Fátima, A. A. Sabino, L. C. Almeida Barbosa and S. A. Fernandes, RSC Adv., 2014, 4, 18612 DOI: 10.1039/C4RA02036G

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