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Issue 27, 2014
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Alternative synthesis of the anti-baldness compound RU58841

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Abstract

RU58841 is active against baldness and is commercially available. The previously reported synthesis uses phosgene, three discrete inert atmosphere steps and three steps that require flash chromatography. Our synthesis uses no phosgene, only one inert atmosphere step and does not require flash chromatography. This is achieved by stepwise construction of the hydantoin moiety around the amino group of 3-trifluoromethyl-4-cyanoaniline and ring closure to give a 2-nitropropane leaving group. On a small scale we achieved an overall yield of 33%.

Graphical abstract: Alternative synthesis of the anti-baldness compound RU58841

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Publication details

The article was received on 13 Jan 2014, accepted on 06 Mar 2014 and first published on 06 Mar 2014


Article type: Paper
DOI: 10.1039/C4RA00332B
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Citation: RSC Adv., 2014,4, 14143-14148
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    Alternative synthesis of the anti-baldness compound RU58841

    M. J. Leonard, A. R. Lingham, J. O. Niere, N. R. C. Jackson, P. G. McKay and H. M. Hügel, RSC Adv., 2014, 4, 14143
    DOI: 10.1039/C4RA00332B

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