One-pot metal-free synthesis of highly substituted pyrroles from 2-acetyl-3-methylene-1,4-dicarbonyl compounds and primary amines via TBHP and activated carbon oxidative aromatization of dihydropyrrole

Abstract

A metal-free one-pot cascade process for the synthesis of 1,2,3,4-tetrasubstituted pyrroles via a tandem enamine, aza-Michael addition and TBHP, activated carbon oxidative aromatization is reported. This strategy features the formation of two C–N bonds in moderate to excellent yields and a broad substrate tolerance.