Issue 13, 2014
From the journal:

RSC Advances

Novel synthesis of thiazolo/thienoazepine-5,8-diones from dihalo cyclic 1,3-diketones and mercaptonitrile salts†

Laichun Luo,a   Lanlan Meng,a   Qi Sun,*a   Zemei Gea  and  Runtao Li*a  

* Corresponding authors

a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
E-mail: sunqi@bjmu.edu.cn, lirt@bjmu.edu.cn
Fax: +86 10 82716956
Tel: +86 82801504

Abstract

An efficient approach to thiazolo[4,5-b]azepine-5,8-diones and thieno[3,2-b]azepine-5,8-diones has been developed via a domino synthesis of multifunctionalized thiazoles/thiophenes and further intramolecular cyclization. This transformation proceeded rapidly under mild conditions without use of metal catalyst.

Graphical abstract: Novel synthesis of thiazolo/thienoazepine-5,8-diones from dihalo cyclic 1,3-diketones and mercaptonitrile salts

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Article information

DOI
https://doi.org/10.1039/C3RA46606J
Article type
Communication
Submitted
12 Nov 2013
Accepted
02 Jan 2014
First published
06 Jan 2014

RSC Adv., 2014,4, 6845-6849

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Novel synthesis of thiazolo/thienoazepine-5,8-diones from dihalo cyclic 1,3-diketones and mercaptonitrile salts

L. Luo, L. Meng, Q. Sun, Z. Ge and R. Li, RSC Adv., 2014, 4, 6845 DOI: 10.1039/C3RA46606J

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