Issue 15, 2014
From the journal:

RSC Advances

Synthesis of a dextran-based bone tracer for in vivo magnetic resonance and optical imaging by two orthogonal coupling reactions†

Hiroshi Tanaka,*a   Sho Yamaguchi,a   Jun-ichiro Jo,b   Ichio Aoki,b   Yasuhiko Tabatac  and  Takashi Takahashi*a  

* Corresponding authors

a Department of Applied Chemistry, Graduate School of Science and Engineering Tokyo Institute of Technology, 2-12-1-H-101 Ookayama, Meguro, Tokyo, Japan
E-mail: thiroshi@apc.titech.ac.jp
Fax: +81 357342884
Tel: +81 357342471

b Molecular Imaging Center, National Institute of Radiological Sciences, Anagawa 4-9-1, Inage, Chiba, Japan
E-mail: aoki@nirs.go.jp
Fax: +81432063276

c Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoinkawaramachi, Sakyo-ku, Kyoto 606–8507, Japan
E-mail: yasuhiko@frontier.kyoto-u.ac.jp
Fax: +81-43-206-3276

Abstract

Synthesis of dextran-based bone tracers for in vivo imaging from a dextran-template containing terminal acetylenes and amino groups though a diethylene glycol spacer is described. The tracer was used to visualize regenerated bone in a BMP-2 installed hydrogel by magnetic resonance and optical imaging.

Graphical abstract: Synthesis of a dextran-based bone tracer for in vivo magnetic resonance and optical imaging by two orthogonal coupling reactions

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Article information

DOI
https://doi.org/10.1039/C3RA46142D
Article type
Communication
Submitted
26 Oct 2013
Accepted
13 Nov 2013
First published
14 Nov 2013

RSC Adv., 2014,4, 7561-7565

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Synthesis of a dextran-based bone tracer for in vivo magnetic resonance and optical imaging by two orthogonal coupling reactions

H. Tanaka, S. Yamaguchi, J. Jo, I. Aoki, Y. Tabata and T. Takahashi, RSC Adv., 2014, 4, 7561 DOI: 10.1039/C3RA46142D

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