Issue 4, 2014
From the journal:

RSC Advances

A cationic morpholino antisense oligomer conjugate: synthesis, cellular uptake and inhibition of Gli1 in the hedgehog signalling pathway†

Sankha Pattanayak,‡a   Harleen Khatra,a   Shekhar Saha§b  and  Surajit Sinha*a  

* Corresponding authors

a Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India
E-mail: ocss5@iacs.res.in
Fax: +91 33 2473 2805
Tel: +91 33 2473 4971

b Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India
Fax: +91 33 2473 2805
Tel: +91 33 2473 4971

Abstract

A guanidinium-linked morpholino pentamer is synthesized and evaluated for cellular penetration properties. A regular morpholino and the pentamer conjugate can exhibit antisense effects when designed against Gli1-transcription factors of the Hh signalling pathway, which is a potential target for cancer therapy. Evidence was found from luciferase assays and western blot analysis.

Graphical abstract: A cationic morpholino antisense oligomer conjugate: synthesis, cellular uptake and inhibition of Gli1 in the hedgehog signalling pathway

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3RA45257C
Article type
Communication
Submitted
24 Jun 2013
Accepted
11 Nov 2013
First published
11 Nov 2013

RSC Adv., 2014,4, 1951-1954

Permissions

Request permissions

A cationic morpholino antisense oligomer conjugate: synthesis, cellular uptake and inhibition of Gli1 in the hedgehog signalling pathway

S. Pattanayak, H. Khatra, S. Saha and S. Sinha, RSC Adv., 2014, 4, 1951 DOI: 10.1039/C3RA45257C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements