Issue 42, 2014

Aerobic oxysulfonylation of alkenes using thiophenols: an efficient one-pot route to β-ketosulfones

Abstract

We have developed a highly efficient synthetic route to β-ketosulfones via AgNO3 catalyzed oxysulfonylation of alkenes using thiophenols in the presence of air (O2) and K2S2O8 as eco-friendly oxidants. Thiophenols have been used as sulfonylation precursors for the first time in a dioxygen activation based radical process. Moreover, the protocol also offers a new and convenient method for the synthesis of β-hydroxysulfides at room temperature without the use of any initiator.

Graphical abstract: Aerobic oxysulfonylation of alkenes using thiophenols: an efficient one-pot route to β-ketosulfones

Supplementary files

Article information

Article type
Paper
Submitted
13 Apr 2014
Accepted
01 Sep 2014
First published
04 Sep 2014

Org. Biomol. Chem., 2014,12, 8550-8554

Aerobic oxysulfonylation of alkenes using thiophenols: an efficient one-pot route to β-ketosulfones

A. K. Singh, R. Chawla, T. Keshari, V. K. Yadav and L. D. S. Yadav, Org. Biomol. Chem., 2014, 12, 8550 DOI: 10.1039/C4OB00776J

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