TFAA/H3PO4 mediated unprecedented N-acylation of carbazoles leading to small molecules possessing anti-proliferative activities against cancer cells

Sunder Kumar Kolli; Bagineni Prasad; P. Vijaya Babu; Mohd Ashraf Ashfaq; Nasreen Z. Ehtesham; R. Ramesh Raju; Manojit Pal

doi:10.1039/C4OB00686K

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TFAA/H₃PO₄ mediated unprecedented N-acylation of carbazoles leading to small molecules possessing anti-proliferative activities against cancer cells†

Sunder Kumar Kolli,^a Bagineni Prasad,^b P. Vijaya Babu,^b Mohd Ashraf Ashfaq,^b Nasreen Z. Ehtesham,^b R. Ramesh Raju*^a and Manojit Pal*^b

Author affiliations

* Corresponding authors

^a Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, A.P., India

^b Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India
E-mail: manojitpal@rediffmail.com
Tel: +91 40 6657 1500

Abstract

For the first time TFAA/H₃PO₄ has facilitated the direct and metal-free N-acylation of carbazoles leading to a number of N-acylated derivatives. Several of these compounds were found to be promising when tested for their anti-proliferative properties against oral cancer cell lines.

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Article information

DOI: https://doi.org/10.1039/C4OB00686K
Article type: Communication
Submitted: 01 Apr 2014
Accepted: 01 Jul 2014
First published: 01 Jul 2014

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Org. Biomol. Chem., 2014,12, 6080-6084

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TFAA/H₃PO₄ mediated unprecedented N-acylation of carbazoles leading to small molecules possessing anti-proliferative activities against cancer cells

S. K. Kolli, B. Prasad, P. V. Babu, M. A. Ashfaq, N. Z. Ehtesham, R. R. Raju and M. Pal, Org. Biomol. Chem., 2014, 12, 6080 DOI: 10.1039/C4OB00686K

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Organic & Biomolecular Chemistry