Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue

M. Scuotto; M. Persico; M. Bucci; V. Vellecco; N. Borbone; E. Morelli; G. Oliviero; E. Novellino; G. Piccialli; G. Cirino; M. Varra; C. Fattorusso; L. Mayol

doi:10.1039/C4OB00149D

Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue†

M. Scuotto,‡^a M. Persico,‡^a M. Bucci,^a V. Vellecco,^a N. Borbone,^a E. Morelli,^a G. Oliviero,^a E. Novellino,^a G. Piccialli,^a G. Cirino,^a M. Varra,*^a C. Fattorusso*^a and L. Mayol^a

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^a Dipartimento di Farmacia, via D. Montesano 49, 80131 Napoli, Italy
E-mail: varra@unina.it, cfattoru@unina.it
Fax: +39 081678552
Tel: +39 081678540

Abstract

Herein, we report optically pure modified acyclic nucleosides as ideal probes for aptamer modification. These new monomers offer unique advantages in exploring the role played in thrombin inhibition by a single residue modification at key positions of the TBA structure.

Organic & Biomolecular Chemistry

Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue†

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Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue

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