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Issue 15, 2014
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NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides

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Abstract

An efficient NHC-catalyzed domino oxidation/oxa-Michael addition reaction of 2-alkenylbenzaldehydes has been developed to afford 3-substituted phthalides bearing a C3-stereogenic center with a broad substrate scope and wide functional group tolerance. The preliminary results of the asymmetric process have been provided as well.

Graphical abstract: NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides

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Supplementary files

Article information


Submitted
20 Dec 2013
Accepted
28 Jan 2014
First published
28 Jan 2014

Org. Biomol. Chem., 2014,12, 2388-2393
Article type
Paper
Author version available

NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides

S. W. Youn, H. S. Song and J. H. Park, Org. Biomol. Chem., 2014, 12, 2388
DOI: 10.1039/C3OB42546K

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