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Issue 21, 2014
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Carbon nanodots prepared from o-phenylenediamine for sensing of Cu2+ ions in cells

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Abstract

A simple hydrothermal method was applied to prepare carbon nanodots (C dots) from o-phenylenediamine (OPD). The C dots exhibit photoluminescence at 567 nm when excited at 420 nm. In the presence of Cu2+ ions, the colour of C dots changes from yellow to orange, with an increased PL intensity as a result of the formation of Cu(OPD)2 complexes on the surfaces of C dots. The D-band to G-band ratios of C dots in the absence and presence of 80 nM Cu2+ ions are 1.31 and 4.75, respectively. The C dots allow the detection of Cu2+ ions with linearity over a concentration range of 2–80 nM, with a limit of detection of 1.8 nM at a signal-to-noise ratio of 3. The cell viability values of A549, MCF-10A, and MDA-MB-231 cells treated with 3 μg mL−1 of C dots are all greater than 99%, showing their great biocompatibility. Having great water dispersibility, photostability, chemical stability (against NaCl up to 0.5 M), great selectivity, and biocompatibility, the C dots have been employed for the localization of Cu2+ ions in the cancer cells (A549 cells) treated with 10 μM Cu2+ ions.

Graphical abstract: Carbon nanodots prepared from o-phenylenediamine for sensing of Cu2+ ions in cells

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Publication details

The article was received on 11 Jun 2014, accepted on 25 Aug 2014 and first published on 28 Aug 2014


Article type: Paper
DOI: 10.1039/C4NR03213F
Citation: Nanoscale, 2014,6, 13119-13125
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    Carbon nanodots prepared from o-phenylenediamine for sensing of Cu2+ ions in cells

    M. Vedamalai, A. P. Periasamy, C. Wang, Y. Tseng, L. Ho, C. Shih and H. Chang, Nanoscale, 2014, 6, 13119
    DOI: 10.1039/C4NR03213F

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