Improved synthesis of bioactive stilbene derivatives applying design of experiments to the Heck–Matsuda reaction

Abstract

Design of experiments was employed to optimize the reaction conditions used to synthesize stilbene derivatives. New Heck conditions were tested using several styrenes and aryldiazonium tetrafluoroborates, generating the desired stilbenes in good yields in all cases under very practical, economical and effective conditions. This methodology was used for the synthesis of bioactive stilbenes such as resveratrol, DMU-212, and their analogues.