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Issue 7, 2014
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ω-Heteroarylalkylcarbamates as inhibitors of fatty acid amide hydrolase (FAAH)

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Abstract

Fatty acid amide hydrolase (FAAH) is a serine hydrolase that terminates the analgetic and anti-inflammatory effects of endocannabinoids such as anandamide. Herein we describe structure–activity relationship studies on a new series of ω-heteroarylalkylcarbamate inhibitors of FAAH. The most active compounds exhibit IC50 values in the low nanomolar range. Investigations on selectivity and metabolic stability of these inhibitors are also presented.

Graphical abstract: ω-Heteroarylalkylcarbamates as inhibitors of fatty acid amide hydrolase (FAAH)

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Publication details

The article was received on 22 Apr 2014, accepted on 15 May 2014 and first published on 16 May 2014


Article type: Concise Article
DOI: 10.1039/C4MD00181H
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Med. Chem. Commun., 2014,5, 932-936
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    ω-Heteroarylalkylcarbamates as inhibitors of fatty acid amide hydrolase (FAAH)

    T. Terwege, H. Dahlhaus, W. Hanekamp and M. Lehr, Med. Chem. Commun., 2014, 5, 932
    DOI: 10.1039/C4MD00181H

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