ω-Heteroarylalkylcarbamates as inhibitors of fatty acid amide hydrolase (FAAH)

Abstract

Fatty acid amide hydrolase (FAAH) is a serine hydrolase that terminates the analgetic and anti-inflammatory effects of endocannabinoids such as anandamide. Herein we describe structure–activity relationship studies on a new series of ω-heteroarylalkylcarbamate inhibitors of FAAH. The most active compounds exhibit IC₅₀ values in the low nanomolar range. Investigations on selectivity and metabolic stability of these inhibitors are also presented.