MMP-8 has been implicated in various diseases. Selective MMP-8 inhibitors are needed to ascertain the role of this enzyme. We synthesized two inhibitors reported previously as selective for MMP-8. Compound 1 selectively inhibited MMP-8 and MMP-13; compound 2 was a potent broad-spectrum inhibitor, notwithstanding that it is used as a selective one.
D. Ding, K. Lichtenwalter, H. Pi, S. Mobashery and M. Chang, Med. Chem. Commun., 2014, 5, 1381 DOI: 10.1039/C4MD00172A
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