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Issue 10, 2014
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HIF-1 promotes the expression of its α-subunit via an epigenetically regulated transactivation loop

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Abstract

Hypoxia inducible factor-1 (HIF-1) directs the cellular response to low oxygen and plays a key role in tumour survival and growth. Here we use an inhibitor of the HIF-1α/HIF-1β protein–protein interaction to show the presence of an epigenetically controlled transactivation loop whereby the HIF-1 transcription factor promotes the expression of its own α-subunit in hypoxic cancer cells.

Graphical abstract: HIF-1 promotes the expression of its α-subunit via an epigenetically regulated transactivation loop

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Supplementary files

Article information


Submitted
16 Jun 2014
Accepted
29 Jul 2014
First published
29 Jul 2014

Mol. BioSyst., 2014,10, 2505-2508
Article type
Communication
Author version available

HIF-1 promotes the expression of its α-subunit via an epigenetically regulated transactivation loop

D. J. Asby, F. Cuda, F. Hoakwie, E. Miranda and A. Tavassoli, Mol. BioSyst., 2014, 10, 2505
DOI: 10.1039/C4MB00351A

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