Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 98, 2014
Previous Article Next Article

Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity

Author affiliations

Abstract

An acid labile branched PDMAEMA/acetal copolymer with amino group was synthesized by the DE-ATRP and followed by Michael addition. The degradation of the polymer was strongly pH-dependent. High nucleic acid transfection efficiency with low cytotoxicity was observed compared to its non-degradable copolymer counterpart.

Graphical abstract: Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity

Back to tab navigation

Supplementary files

Article information


Submitted
28 Aug 2014
Accepted
20 Oct 2014
First published
22 Oct 2014

Chem. Commun., 2014,50, 15565-15568
Article type
Communication

Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity

H. L. Cao, Y. X. Dong, A. Aied, T. Y. Zhao, X. Chen, W. X. Wang and A. Pandit, Chem. Commun., 2014, 50, 15565
DOI: 10.1039/C4CC06728B

Social activity

Search articles by author

Spotlight

Advertisements