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Issue 78, 2014
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An octadentate bifunctional chelating agent for the development of stable zirconium-89 based molecular imaging probes

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Abstract

89Zr-based imaging agents hold great promise as novel radio-tracers in nuclear medicine. However, insufficient stability of currently used radiometal complexes in vivo is a safety concern for clinical applications. We herein report the first octadentate bifunctional chelating agent for the development of 89Zr-labelled (bio)conjugates with improved stability.

Graphical abstract: An octadentate bifunctional chelating agent for the development of stable zirconium-89 based molecular imaging probes

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The article was received on 18 Jul 2014, accepted on 13 Aug 2014 and first published on 13 Aug 2014


Article type: Communication
DOI: 10.1039/C4CC05558F
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Citation: Chem. Commun., 2014,50, 11523-11525
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    An octadentate bifunctional chelating agent for the development of stable zirconium-89 based molecular imaging probes

    M. Patra, A. Bauman, C. Mari, C. A. Fischer, O. Blacque, D. Häussinger, G. Gasser and T. L. Mindt, Chem. Commun., 2014, 50, 11523
    DOI: 10.1039/C4CC05558F

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