Issue 79, 2014
From the journal:

Chemical Communications

A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum†

Zhigang Yang,a   Yanxia He,a   Jae Hong Lee,a   Weon-Sik Chae,b   Wen Xiu Ren,a   Joung Hae Lee,c   Chulhun Kang*d  and  Jong Seung Kim*a  

* Corresponding authors

a Department of Chemistry, Korea University, Seoul 136-701, Korea
E-mail: jongskim@korea.ac.kr

b Gangneung Center, Korea Basic Science Institute, Gangneung 210-702, Korea

c Korea Research Institute of Standards and Science, Daejon 305-600, Korea

d The School of East-West Medical Science, Kyung Hee University, Yongin 446-701, Korea
E-mail: kangch@khu.ac.kr

Abstract

We herein report a fluorescent bimodal probe (1) capable of determining ER viscosity and polarity changes using FLIM and fluorescence ratiometry, respectively; during ER stress caused by tunicamycin, the viscosity was increased from ca. 129.5 to 182.0 cP and the polarity of the ER (dielectric constant, ε) enhanced from 18.5 to 21.1.

Graphical abstract: A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum

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Article information

DOI
https://doi.org/10.1039/C4CC04915B
Article type
Communication
Submitted
27 Jun 2014
Accepted
08 Aug 2014
First published
08 Aug 2014

Chem. Commun., 2014,50, 11672-11675

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A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum

Z. Yang, Y. He, J. H. Lee, W. Chae, W. X. Ren, J. H. Lee, C. Kang and J. S. Kim, Chem. Commun., 2014, 50, 11672 DOI: 10.1039/C4CC04915B

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