Dehydrocoronamic acid can be racemised by dehydration of an N-acyl derivative to an azlactone, which undergoes facile racemisation. For the N-trifluoroacetyl derivative, the racemisation process was combined with an enzymatic resolution, to achieve a dynamic kinetic resolution process by which the racemate can be converted to either enantiomer.
D. A. Chaplin, M. E. Fox and S. H. B. Kroll, Chem. Commun., 2014, 50, 5858 DOI: 10.1039/C4CC01125B
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