Amino group binding peptide aptamers with double disulphide-bridged loops selected by in vitro selection using cDNA display

Abstract

Peptide aptamers that specifically bind to the amino group on a solid-phase were screened by in vitro selection using the cDNA display method. The identified peptides have a unique structure containing two cyclic loops with disulphide bonds and a linkage region, which were indispensable for molecular recognition.