Issue 54, 2014
From the journal:

Chemical Communications

A “light-up” and “spectrum-shift” response of aptamer-functionalized silver nanoclusters for intracellular mRNA imaging†

Jingjing Li,ab   Jia You,b   Yinping Zhuang,b   Cuiping Han,ab   Junfeng Hu,b   Aming Wang,b   Kai Xu*ab  and  Jun-Jie Zhu*c  

* Corresponding authors

a Department of Radiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006, China
E-mail: xkpaper@163.com

b School of Medical Imaging, Xuzhou Medical College, Xuzhou 221004, China

c State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
E-mail: jjzhu@nju.edu.cn

Abstract

We have designed a novel multifunctional DNA scaffold for the synthesis of fluorescent silver nanoclusters (Ag NCs) using a one-pot approach. The obtained DNA/Ag NCs presented a “light-up” and “spectrum-shift” response to target DNA in vitro and could further image the tumor-related mRNA in living cells.

Graphical abstract: A “light-up” and “spectrum-shift” response of aptamer-functionalized silver nanoclusters for intracellular mRNA imaging

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Article information

DOI
https://doi.org/10.1039/C4CC00160E
Article type
Communication
Submitted
08 Jan 2014
Accepted
21 Mar 2014
First published
21 Mar 2014

Chem. Commun., 2014,50, 7107-7110

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A “light-up” and “spectrum-shift” response of aptamer-functionalized silver nanoclusters for intracellular mRNA imaging

J. Li, J. You, Y. Zhuang, C. Han, J. Hu, A. Wang, K. Xu and J. Zhu, Chem. Commun., 2014, 50, 7107 DOI: 10.1039/C4CC00160E

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