Direct access to isoindolines through tandem Rh(III)-catalyzed alkenylation and cyclization of N-benzyltriflamides

Neeraj Kumar Mishra; Jihye Park; Satyasheel Sharma; Sangil Han; Mirim Kim; Youngmi Shin; Jinbong Jang; Jong Hwan Kwak; Young Hoon Jung; In Su Kim

doi:10.1039/C3CC49486A

Direct access to isoindolines through tandem Rh(iii)-catalyzed alkenylation and cyclization of N-benzyltriflamides†

Neeraj Kumar Mishra,^a Jihye Park,^a Satyasheel Sharma,^a Sangil Han,^a Mirim Kim,^a Youngmi Shin,^a Jinbong Jang,^a Jong Hwan Kwak,^a Young Hoon Jung^a and In Su Kim*^a

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^a School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea
E-mail: insukim@skku.edu
Fax: +82 31 292 8800
Tel: +82 31 290 7788

Abstract

The rhodium-catalyzed oxidative alkenylation of N-benzyltriflamides with olefins followed by an intramolecular cyclization via C–H bond activation is described. This method results in the direct and efficient synthesis of highly substituted isoindoline frameworks.

Chemical Communications

Direct access to isoindolines through tandem Rh(iii)-catalyzed alkenylation and cyclization of N-benzyltriflamides†

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Direct access to isoindolines through tandem Rh(III)-catalyzed alkenylation and cyclization of N-benzyltriflamides

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