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Issue 47, 2013
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Amphiphilic peptoid transporters – synthesis and evaluation

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Abstract

Cell-penetrating peptoids are an important class of peptidomimetics, which can replace highly biodegradable cell penetrating peptides for enhanced drug delivery. Typically, they contain positively charged amino side chains which are synthesized via their protected analogues. To avoid the use of amine protecting groups a Click-chemistry based modular synthesis of novel hydrophilic as well as amphiphilic cell penetrating peptoids was developed to generate novel structures for drug delivery in cells.

Graphical abstract: Amphiphilic peptoid transporters – synthesis and evaluation

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Publication details

The article was received on 01 Jun 2013, accepted on 03 Oct 2013 and first published on 03 Oct 2013


Article type: Paper
DOI: 10.1039/C3OB41139G
Citation: Org. Biomol. Chem., 2013,11, 8197-8201
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    Amphiphilic peptoid transporters – synthesis and evaluation

    S. B. L. Vollrath, D. Fürniss, U. Schepers and S. Bräse, Org. Biomol. Chem., 2013, 11, 8197
    DOI: 10.1039/C3OB41139G

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