1,2,3-Triazoles as versatile directing group for selective sp2 and sp3 C–H activation: cyclizationvs substitution

Abstract

Selective cyclization and substitution was achieved with designated 1,2,3-triazole acid auxiliary groups under Pd catalyzed C–H activation conditions. Both sp² and sp³ C–H bonds were effectively activated, giving the desired products in good yields. This result revealed the first successful example of exclusive substitution using 1,2,3-triazole ligands, while another triazole-containing directing group dominantly gave cyclization under identical conditions.