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Issue 45, 2013
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Chemo-enzymatic synthesis of valrubicin using Pluronic conjugated lipase with temperature responsiveness in organic media

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Abstract

A novel synthetic route for valrubicin, an anti-cancer drug, was proposed using a temperature-responsive lipase–Pluronic conjugate which gave an overall yield of 82% and a purity of 98% under mild conditions (50 °C, 6–8 h). The high activity, stability, selectivity and reusability of this new lipase catalyst hold great promise for practical applications.

Graphical abstract: Chemo-enzymatic synthesis of valrubicin using Pluronic conjugated lipase with temperature responsiveness in organic media

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Publication details

The article was received on 04 Sep 2013, accepted on 02 Oct 2013 and first published on 03 Oct 2013


Article type: Communication
DOI: 10.1039/C3RA44879G
Citation: RSC Adv., 2013,3, 22963-22966
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    Chemo-enzymatic synthesis of valrubicin using Pluronic conjugated lipase with temperature responsiveness in organic media

    Y. Zhang, Y. Dai, M. Hou, T. Li, J. Ge and Z. Liu, RSC Adv., 2013, 3, 22963
    DOI: 10.1039/C3RA44879G

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