Issue 45, 2013
From the journal:

RSC Advances

Copper-catalyzed synthesis of 1,2,4-trisubstituted pyrroles via cascade reactions of aryloxy-enynes with amines†

Ende Li,a   Xingcan Cheng,a   Chengyu Wang,a   Xia Suna  and  Yanzhong Li*a  

* Corresponding authors

a Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 500 Dongchuan Road, Shanghai, People's Republic of China
E-mail: yzli@chem.ecnu.edu.cn
Fax: +86-021-54340096

Abstract

A highly efficient copper-catalyzed cascade reaction of aryloxy-enynes with amines under mild reaction conditions has been developed. This methodology offers rapid access to 1,2,4-trisubstituted pyrroles in good to excellent yields in a regioselective manner.

Graphical abstract: Copper-catalyzed synthesis of 1,2,4-trisubstituted pyrroles via cascade reactions of aryloxy-enynes with amines

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Article information

DOI
https://doi.org/10.1039/C3RA44595J
Article type
Communication
Submitted
22 Aug 2013
Accepted
30 Sep 2013
First published
01 Oct 2013

RSC Adv., 2013,3, 22872-22876

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Copper-catalyzed synthesis of 1,2,4-trisubstituted pyrroles via cascade reactions of aryloxy-enynes with amines

E. Li, X. Cheng, C. Wang, X. Sun and Y. Li, RSC Adv., 2013, 3, 22872 DOI: 10.1039/C3RA44595J

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