Issue 43, 2013
From the journal:

RSC Advances

Copper-catalyzed direct cross-coupling of 1,3,4-oxadiazoles with N-tosylhydrazones: efficient synthesis of benzylated 1,3,4-oxadiazoles†‡

N. Salvanna,a   Gandolla Chinna Reddy,a   Bethapudi Rama Raoa  and  Biswanath Das*a  

* Corresponding authors

a Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India
E-mail: biswanathdas@yahoo.com
Fax: +91-40-27193198

Abstract

The first copper catalyzed direct C–H benzylation of 1,3,4-oxadiazoles using N-tosylhydrazones has efficiently been accomplished. Several substituted oxadiazoles have been prepared in high yields (80–89%) in 3 h.

Graphical abstract: Copper-catalyzed direct cross-coupling of 1,3,4-oxadiazoles with N-tosylhydrazones: efficient synthesis of benzylated 1,3,4-oxadiazoles

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Article information

DOI
https://doi.org/10.1039/C3RA42791A
Article type
Paper
Submitted
06 Jun 2013
Accepted
21 Aug 2013
First published
09 Sep 2013

RSC Adv., 2013,3, 20538-20544

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Copper-catalyzed direct cross-coupling of 1,3,4-oxadiazoles with N-tosylhydrazones: efficient synthesis of benzylated 1,3,4-oxadiazoles

N. Salvanna, G. C. Reddy, B. R. Rao and B. Das, RSC Adv., 2013, 3, 20538 DOI: 10.1039/C3RA42791A

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