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Issue 40, 2013
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Catalytic synthesis of enantiopure mixed diacylglycerols – synthesis of a major M. tuberculosis phospholipid and platelet activating factor

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Abstract

An efficient catalytic one-pot synthesis of TBDMS-protected diacylglycerols has been developed, starting from enantiopure glycidol. Subsequent migration-free deprotection leads to stereo- and regiochemically pure diacylglycerols. This novel strategy has been applied to the synthesis of a major Mycobacterium tuberculosis phospholipid, its desmethyl analogue, and platelet activating factor.

Graphical abstract: Catalytic synthesis of enantiopure mixed diacylglycerols – synthesis of a major M. tuberculosis phospholipid and platelet activating factor

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Publication details

The article was received on 18 Jul 2013, accepted on 22 Aug 2013 and first published on 23 Aug 2013


Article type: Paper
DOI: 10.1039/C3OB41483C
Citation: Org. Biomol. Chem., 2013,11, 6919-6928

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    Catalytic synthesis of enantiopure mixed diacylglycerols – synthesis of a major M. tuberculosis phospholipid and platelet activating factor

    P. Fodran and A. J. Minnaard, Org. Biomol. Chem., 2013, 11, 6919
    DOI: 10.1039/C3OB41483C

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